The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa

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The significance of antineutrophil cytoplasmic antibody in microscopic polyangitis and classic polyarteritis nodosa.

AIMS To describe the distribution and features of classic polyarteritis nodosa (PAN) and microscopic polyarteritis (MPA) and the importance of antineutrophil cytoplasmic antibody (ANCA) in childhood PAN. METHODS Classic PAN was diagnosed in 15 patients based on the presence of aneurysms on angiography in 10 patients and of necrotising vasculitis in medium sized arteries in five. MPA was diagn...

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pANCA Positive Classic Polyarteritis Nodosa

This 62 years old male presented with progressive weakness of upper and lower limbs since 3 months which was subacute, asymmetrical in onset and painful. It began on the right side and went over to the left (Rt UL → Rt LL → Lt UL and LL) but there was no bladder involvement. He had associated low grade fever off and on. He received IV steroids (alternate day dexamethasone injection) followed by...

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The spectrum of renal disease associated with microscopic polyangiitis and classic polyarteritis nodosa in Kuwait.

BACKGROUND This study was conducted to examine prospectively the epidemiological profile of renal disease associated with microscopic polyangiitis (MPA) and classic polyarteritis nodosa (classic PAN) in Kuwait and its clinicopathological correlation. METHODS Between 1 January 1993 and 31 December 1996, all patients referred to Al-Amiri renal centre were subjected to renal biopsy and/or arteri...

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Antineutrophil cytoplasmic antibody associated microscopic polyangiitis and sinobronchial syndrome.

Antineutrophil cytoplasmic antibodies (ANCA)are well known to be associated with small sized vessel vasculitic diseases such as microscopic polyangiitis (MPA), allergic granulomatous angiitis (AGA), and Wegener's granulomatosis (WG) (1). One subtype is an antibody against myeloperoxidase (MPO), which stains in a perinuclear pattern (P ANCA)by indirect immunofluorescence (IIF) using a neutrophil...

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Polyarteritis Nodosa

POLYARTERITIs NODosA, as its niame implies, is ain inflammatory lesion involving the -whole three coats of the arterial system in a noclal manner. The causation of this is unknown, but its peculiar affinity for wi(despread involvement of the smaller arteries results in a multiplicity of clinical signs and symptoms, and leads to confusion and difficulty in diagnosis. The more severely affected o...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 2001

ISSN: 0003-9888

DOI: 10.1136/adc.85.5.427